FLEXBUMIN®
METHOD OF ADMINISTRATION
Twist off the blue
protective cap.9
Using a twisting motion, firmly insert the spike of the non-vented IV set into the administration port.9
Ensure the spike is firmly inserted into the port.9
FLEXBUMIN® CAN BE DIRECTLY ADMINISTERED BY THE INTRAVENOUS ROUTE,
using a disposable sterile and pyrogen free infusion set. Before inserting the infusion set in the cap, this should be disinfected with an appropriate antiseptic. Once the infusion set is attached to the bag, the content should be perfused immediately.4
FLEXBUMIN® CAN BE DILUTED IN AN ISOTONIC SOLUTION
(e.g. 5% glucose or 0.9% sodium chloride). Albumin solutions must not be diluted with water for injections as this may cause hemolysis in recipients. If large volumes are administered, the product should be warmed to room or body temperature before use. Do not use solutions which are cloudy or have deposits. This may indicate that the protein is unstable or that the solution has become contaminated. Use only if the seal is intact. Discard in case of leak. The contents must not be used more than 4 hours after the container is penetrated and any remnant portion must be discarded. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. 4
REFERENCES
- The Joint Commission. Preventing Central Line-Associated Bloodstream Infections: A Global Challenge, A Global Perspective. Oak Brook, IL: Joint Commission Resources; May 2012. Accessed November 2020. https://www.jointcommission.org/-/media/deprecated-unorganized/imported-assets/tic/system-folders/topics-library/clabsi_monographpdf.pdf?db=web&hash=86103821F3C7FF8A7683C933EA0CB391
- Four-layer bag technology - Ref-35896- Baxter - May 2017.
- Maki DG, et al. Impact of Switching from an Open to a Closed Infusion System on Rates of Central Line-Associated Bloodstream Infection: A Meta-analysis of Time-Sequence Cohort Studies in 4 Countries. Infect Control Hosp Epidemiol. 2011;32:50-58.
- Flexbumin India Prescribing Information (PI).
- Jarvis WR, et al. INICC Care Bundles to Prevent Central and Peripheral Line-Related Bloodstream Infections. International Nosocomial Infection Control Consortium. 2017:1-49. Accessed November 2020. http://www.inicc.org/media/docs/2017-INICCBSIPreventionGuidelines.pdf
- O'Grady NP, et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections, 2011. Updated 2017. Accessed November 2020. https://www.cdc.gov/infectioncontrol/quidelines/bsi/index.html
- Orsi GB, et al. Hospital-acquired, laboratory-confirmed bloodstream infection: increased hospital stay and direct costs. Infect Control Hosp Epidemiol 2002:23(4):190-197.
- Summary Report of Observations for Flexbumin bags and Buminate bottles. Shire, Data on File. ID: FLEX-005. July 2017.
- Viaflo Key Features User Guide - June 2014.
