CLABSIs JEOPARDIZE YOUR PATIENT'S
HEALTH AND RECOVERY1
FLEXBUMIN®
is designed to help
reduce the risk of CLABSIs
when patients require an albumin therapy.2,3
A SWITCH
from an open to a closed infusion system significantly decreased CLABSI incidence and all-cause ICU* mortality.3
In a meta-analysis of 4 identical cohorts in 4,373 patients from 15 intensive care units in 7 hospitals (Argentina, Brazil, Italy, Mexico), the impact of switching from open (n=2,237 patients; 8-12 months) to closed (n=2,136 patients; 6-12 months) systems on CLABSI rates and all-cause ICU* mortality was evaluated.3
Data presented is not in relation to FLEXBUMIN® specifically, but rather to open versus closed systems generally
*Intensive Care Unit
Overall CLABSI risk decreased by
67%
with a closed infusion system3
- Open container: 10.1 (153 CLABSI/15,189 CL-days)
- Closed container: 3.3 (45 CLABSI/13,456 CL-days)
- RR = 0.33 [95% CI, 0.24-0.46]
- Open container: 22.0% (493 deaths/2,237 patients)
- Closed container: 16.9% (362 deaths/2,136 patients)
- RR = 0.77 [95% CI, 0.68-0.87]
Relative mortality risk decreased by
23%
with a closed infusion system3
In a meta-analysis of 4 identical cohorts in 4,373 patients from 15 adult ICUs in 7 hospitals (Argentina, Brazil, Italy, Mexico), the impact of switching from open (n = 2,237 patients; 8-12 months) to closed (n = 2,136 patients; 6-12 months) systems on CLABSI rates and all-cause ICU mortality was evaluated.3,*
Overall CLABSI risk decreased by
67%
with a closed infusion system3
- Open container: 10.1 (153 CLABSI/15,189 CL-days)
- Closed container: 3.3 (45 CLABSI/13,456 CL-days)
- RR = 0.33 [95% CI, 0.24-0.46]
- Open container: 22.0% (493 deaths/2,237 patients)
- Closed container: 16.9% (362 deaths/2,136 patients)
- RR = 0.77 [95% CI, 0.68-0.87]
Relative mortality risk decreased by
23%
with a closed infusion system3
In a meta-analysis of 4 identical cohorts in 4,373 patients from 15 adult ICUs in 7 hospitals (Argentina, Brazil, Italy, Mexico), the impact of switching from open (n = 2,237 patients; 8-12 months) to closed (n = 2,136 patients; 6-12 months) systems on CLABSI rates and all-cause ICU mortality was evaluated.3,*
Closed infusion systems are recommended by international bodies for safety, infection control and reduced CLABSI ourbreaks.1,5,6
CLABSIs
have a consequential economic burden7
leading to increased costs, morbidity and mortality.1
In a retrospective historical cohort study (N=105) with 1:2 matching in ICUs and surgical wards in Italy, direct cost and increased hospital stay that were attributable to CLABSIs were determined. 7
Data presented is not in relation to FLEXBUMIN® specifically, but rather to open versus closed systems generally
With closed infusion systems, as well as other essential hygiene and technique measures, you can reduce the risk of CLABSIs. 1-7
Choose FLEXBUMIN® for your patients requiring albumin therapy
REFERENCES
- The Joint Commission. Preventing Central Line-Associated Bloodstream Infections: A Global Challenge, A Global Perspective. Oak Brook, IL: Joint Commission Resources; May 2012. Accessed November 2020. https://www.jointcommission.org/-/media/deprecated-unorganized/imported-assets/tic/system-folders/topics-library/clabsi_monographpdf.pdf?db=web&hash=86103821F3C7FF8A7683C933EA0CB391
- Four-layer bag technology - Ref-35896- Baxter - May 2017.
- Maki DG, et al. Impact of Switching from an Open to a Closed Infusion System on Rates of Central Line-Associated Bloodstream Infection: A Meta-analysis of Time-Sequence Cohort Studies in 4 Countries. Infect Control Hosp Epidemiol. 2011;32:50-58.
- Flexbumin India Prescribing Information (PI).
- Jarvis WR, et al. INICC Care Bundles to Prevent Central and Peripheral Line-Related Bloodstream Infections. International Nosocomial Infection Control Consortium. 2017:1-49. Accessed November 2020. http://www.inicc.org/media/docs/2017-INICCBSIPreventionGuidelines.pdf
- O'Grady NP, et al. Guidelines for the Prevention of Intravascular Catheter-Related Infections, 2011. Updated 2017. Accessed November 2020. https://www.cdc.gov/infectioncontrol/quidelines/bsi/index.html
- Orsi GB, et al. Hospital-acquired, laboratory-confirmed bloodstream infection: increased hospital stay and direct costs. Infect Control Hosp Epidemiol 2002:23(4):190-197.
- Summary Report of Observations for Flexbumin bags and Buminate bottles. Shire, Data on File. ID: FLEX-005. July 2017.
- Viaflo Key Features User Guide - June 2014.
